Ac-CoA Synthase Inhibitor1_product_DataBase

Bioactivity

Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 µM[1]. Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV)[2].

Invitro

Ac-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 µM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 µM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 µM[1].

Name

Ac-CoA Synthase Inhibitor1

CAS

508186-14-9

Formula

C20H18N4O2S2

Molar Mass

410.51

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Sarah A Comerford, et al. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602. [2]. Bill Severson, et al. Anti-viral treatment and assay to screen for anti-viral agent. WO 2011097607 A1

PeptideDB

Ac-CoA Synthase Inhibitor1

CAS: 508186-14-9 F: C20H18N4O2S2 W: 410.51