| Bioactivity | AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R)[1][2]. |
| Target | IC50: 6 nM (CSF1R) |
| Invitro | AZ683对犬心肌细胞l型Ca通道电流的抑制IC50 3.5 μM，对人心脏NaV1.5通道的抑制IC50 14 μM [2] MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AZ683 相关抗体: |
| CAS | 953798-95-3 |
| Formula | C23H25F2N5O2 |
| Molar Mass | 441.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tanzey SS, et al. Synthesis and Initial In Vivo Evaluation of [11C]AZ683-A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R). Pharmaceuticals (Basel). 2018 Dec 13;11(4):136. [2]. Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. |