ATPγS tetralithium salt_product_DataBase

Bioactivity	ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1].
Invitro	ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1].ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3].
In Vivo	ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3].ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].
Name	ATPγS tetralithium salt
CAS	93839-89-5
Formula	C10H12Li4N5O12P3S
Molar Mass	546.98
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. [2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. [3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24.

PeptideDB

ATPγS tetralithium salt

CAS: 93839-89-5 F: C10H12Li4N5O12P3S W: 546.98