| Bioactivity | AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4]. | ||||||||||||
| Invitro | AG126 (10 μM; overnight) increases the viability of ARPE-19 cells[2].AG126 at concentrations higher than 10 μM show toxic to ARPE-19 cells and can enhance H2O2 toxicity[2].AG126 (0.1-100 μM) inhibits VEGF-induced proliferation of BRMECs[4]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| In Vivo | AG 126 (intraperitoneal injection; 1-10 mg/kg; 1 h and 6 h after Zymosan treatment) treatment attenuates the degree of multiple organ failure (MOF) associated with Zymosan-induced peritonitis in the rat[3]. Animal Model: | ||||||||||||
| Name | AG126 | ||||||||||||
| CAS | 118409-62-4 | ||||||||||||
| Formula | C10H5N3O3 | ||||||||||||
| Molar Mass | 215.17 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157(1):145-58. [2]. Garg TK, et al. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5. [3]. Dugo L, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Intensive Care Med. 2002 Jun;28(6):775-88. [4]. Bullard LE, et al. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1722-31. |