| Bioactivity | ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD)[1][2]. | ||||||
| Invitro | ABT-510 acetate (1，5，10，20，50 nM；24 h) 诱导 ID 8 细胞凋亡，增加人类上皮性癌症细胞系 SKOV3、OVCAR3 和 CAOV3 的凋亡发生率[1]。ABT-510 acetate (0-10 μM；7 天) 抑制了 NO 刺激的血管细胞向细胞外基质的生长和侵袭。ABT-510 acetate 可阻断肿瘤驱动的血管细胞生长、NO 驱动的 cGMP 通量以及 CD36 介导的脂肪酸吸收。[3]。 Apoptosis Analysis[1] Cell Line: | ||||||
| In Vivo | ABT-510 acetate (100 mg/kg；腹腔注射；每天一次，持续90天) 在体内诱导细胞凋亡，使小鼠的上皮卵巢肿瘤大小、腹水量和继发性病变扩散显著减少[1]。ABT-510 acetate (60 mg/kg；皮下渗透微型泵；每天一次，持续7天) 降低炎症性肠病小鼠模型中的血管生成和炎症[2]。 Animal Model: | ||||||
| Name | ABT-510 acetate | ||||||
| CAS | 442526-87-6 | ||||||
| Formula | C48H87N13O13 | ||||||
| Molar Mass | 1054.28 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Greenaway J, et.al. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8(1):64-74. [2]. Punekar S,et.al. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008;75(1):9-21. [3]. Isenberg JS, et.al. Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells. Biochem Pharmacol. 2008 Feb 15;75(4):875-82. |
ABT-510 acetate
CAS: 442526-87-6 F: C48H87N13O13 W: 1054.28
ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovaria
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