9-Hydroxyoctadecanoic acid_product_DataBase

Bioactivity

9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1].

Invitro

9-Hydroxyoctadecanoic acid (9-HSA) 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。9-Hydroxyoctadecanoic acid (9-HSA) (100 μM; 24 h) 抑制 HT29 细胞增殖，诱导 G0/G1 阻滞，并在转录和翻译水平上增加 p21WAF1 表达[2]。 Cell Proliferation Assay9-Hydroxyoctadecanoic acid 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。 Cell Line:

Name

9-Hydroxyoctadecanoic acid

CAS

3384-24-5

Formula

C18H36O3

Molar Mass

300.48

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Calonghi N, et al. Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J Lipid Res. 2005 Aug;46(8):1596-603. [2]. Calonghi N, et al. 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004 Jan 30;314(1):138-42.

PeptideDB

9-Hydroxyoctadecanoic acid

CAS: 3384-24-5 F: C18H36O3 W: 300.48