Bioactivity | 8-Chloro-cAMP sodium is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP sodium has anticancer activity[1]. |
Invitro | 8-Chloro-cAMP sodium markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 8-Chloro-cAMP sodium 相关抗体: |
In Vivo | In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) sodium reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
CAS | 124705-03-9 |
Formula | C10H10ClN5NaO6P |
Molar Mass | 385.63 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. C Indolfi, et al. 8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo. J Am Coll Cardiol. 2000 Jul;36(1):288-93. |