| Bioactivity | 8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1]. |
| Invitro | 8-Br-GTP inhibits FtsZ polymerization but does not affect tubulin polymerization.8-Br-GTP has two stable orientations of the base toward the sugar: anti and syn. 8-Br-GTP shows preference for the syn conformation (population ~90%)[1][2]. |
| Name | 8-Br-GTP |
| CAS | 23197-98-0 |
| Formula | C10H15BrN5O14P3 |
| Molar Mass | 602.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44(21):7879-84. [2]. Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127(20):204104. |
8-Br-GTP
CAS: 23197-98-0 F: C10H15BrN5O14P3 W: 602.08
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP ca
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