6-Deoxyjacareubin_product_DataBase

Bioactivity	6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].
Invitro	6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。
In Vivo	6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. Animal Model:
Name	6-Deoxyjacareubin
CAS	16265-56-8
Formula	C18H14O5
Molar Mass	310.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51.

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