| Bioactivity | 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3]. |
| Invitro | 5-PAHSA (30 μM，12 小时) 可降低 PC12 细胞中 ROS 水平并诱导自噬[1]。5-PAHSA (20 μM，2 天) 可降低 HepG2 细胞和 3T3-L1 细胞中高胰岛素和 TNF-α 诱导的胰岛素抵抗[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 5-PAHSA 相关抗体: |
| In Vivo | 5-PAHSA (50 和 150 mg/kg，口服灌胃，30 天) 抑制 DB/DB 小鼠的脂质过氧化[1]。5-PAHSA (45 mg/kg，口服灌胃，3 天) 在小鼠寒冷暴露期间刺激附睾 WAT (eWAT) 的从头脂肪生成和脂质重塑[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1481636-41-2 |
| Formula | C34H66O4 |
| Molar Mass | 538.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang JT, et al. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27(4):484-496. [2]. Paluchova V, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69(3):300-312. [3]. Wang YM, et al. High Glucose Concentration Impairs 5-PAHSA Activity by Inhibiting AMP-Activated Protein Kinase Activation and Promoting Nuclear Factor-Kappa-B-Mediated Inflammation. Front Pharmacol. 2019 Jan 7;9:1491. |