| Bioactivity | 5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1].Pharmacokinetic Analysis ICR Male Mice[1]药代动力学分析[1] Plasma |
| Invitro | 5-HT7R antagonist 2 (compound 4h) (microsomes, 30 分钟) 具有显著的代谢稳定性，对细胞无毒性[1]。5-HT7R antagonist 2 在 G 蛋白和 β-阻滞蛋白信号通路中都是一种竞争性拮抗剂[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 5-HT7R antagonist 2 相关抗体: Cell Line: |
| In Vivo | 5-HT7R antagonist (compound 4h) （腹腔内注射，5 mg/kg，30 分钟）在 ASD 动物模型中具有调节 ASD 重复行为的潜力，能增加 ASD 未成熟神经元的数量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1448808-50-1 |
| Formula | C16H16N2O |
| Molar Mass | 252.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jeong JH, et al. Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R. ACS Chem Neurosci. 2024;15(5):1026-1041. |
5-HT7R antagonist 2
CAS: 1448808-50-1 F: C16H16N2O W: 252.31
5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathwa
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