| Bioactivity | 5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Butenolide disrupts the mitochondrial membrane potential in primary neonatal rat cardiomyocytes. 5-Acetamide-Butenolide also induces the production of thiobarbituric acid reactive substances (TBARS) in isolated rat myocardial mitochondria. 5-Acetamide-Butenolide increases the production of reactive oxygen species (ROS), decreases the levels of GSH and reduces the viability of HepG2 cells[1][2][3]. |
| CAS | 16275-44-8 |
| Formula | C6H7NO3 |
| Molar Mass | 141.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yates S G, et al. Mycotoxins produced by Fusarium nivale isolated from tall fescue (Festuca arundinacea Schreb.)[J]. Phytochemistry, 1968, 7(1): 139-146. [2]. Wang YM, et al. Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. Toxicol Mech Methods. 2009 Feb;19(2):79-85. [3]. Wang YM, et al. Depletion of intracellular glutathione mediates butenolide-induced cytotoxicity in HepG2 cells. Toxicol Lett. 2006 Jul 14;164(3):231-8. |
5-Acetamide-Butenolide
CAS: 16275-44-8 F: C6H7NO3 W: 141.12
5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Bu
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