| Bioactivity | 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol is a bibenzyl compound derived from Dendrobium nobile. 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol shows promising therapeutic potential against cancer cells. 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol is a novel inhibitor of the Wnt/β-catenin pathway. | ||||||||||||
| Target | Wnt | ||||||||||||
| Invitro | 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol reduces the level of phosphorylated LRP6[1]. 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC50 value is 9.30 µM[2]. | ||||||||||||
| In Vivo | LDD and 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats[2]. | ||||||||||||
| Name | 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol | ||||||||||||
| CAS | 67884-30-4 | ||||||||||||
| Formula | C16H18O4 | ||||||||||||
| Molar Mass | 274.31 | ||||||||||||
| Appearance | Oil | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yu S, et al. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med. 2018 Feb 14;18(1):59. [2]. Chen H, et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway. Oncol Rep. 2017 Feb;37(2):865-870. [3]. Déciga-Campos M, et al. Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. J Ethnopharmacol. 2007 Nov 1;114(2):161-8. |
5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol
CAS: 67884-30-4 F: C16H18O4 W: 274.31
5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol is a bibenzyl compound derived from Dendrobium nobile. 5-(3-Hydroxy-5-m
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