5,5'-Difluoro BAPTA_product_DataBase

Bioactivity	5,5'-Difluoro BAPTA is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA is the most widely used probe for studying cytosolic free Ca2+ by 19F NMR. 5,5'-Difluoro BAPTA has high selectivity for Ca2+. 5,5'-Difluoro BAPTA can inhibit the growth of pollen tube[1][2].
Invitro	5,5'-Difluoro BAPTA shows large 19F NMR chemical shifts upon chelating divalent cations[1].Fe2+ ion concentrations were measured following addition of 5 mM 5,5'-Difluoro BAPTA to the culture medium. Fe2+ forms a complex with 5,5'-Difluoro BAPTA (Kd=50 nM) that exhibits a characteristic peak down-field from biological ions such as Ca2+ and Zn2+[3].
Name	5,5'-Difluoro BAPTA
CAS	156027-00-8
Formula	C34H38F2N2O18
Molar Mass	800.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bar-Shir A, et al. Metal ion sensing using ion chemical exchange saturation transfer 19F magnetic resonance imaging. J Am Chem Soc. 2013 Aug 21;135(33):12164-7. [2]. Pierson ES, et al. Pollen tube growth is coupled to the extracellular calcium ion flux and the intracellular calcium gradient: effect of BAPTA-type buffers and hypertonic media. Plant Cell. 1994 Dec;6(12):1815-28. [3]. Kostellow AB, et al. Iron-catalyzed lipid peroxidation in aortic cells in vitro: protective effect of extracellular magnesium. Atherosclerosis. 2004 Jul;175(1):15-22.

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