4-(Chloromethyl)-7-hydroxycoumarin_product_DataBase

Bioactivity	4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].
Name	4-(Chloromethyl)-7-hydroxycoumarin
CAS	25392-41-0
Formula	C10H7ClO3
Molar Mass	210.61
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Reference	[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783. [2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters,

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