3-Methyl-GABA_product_DataBase

Bioactivity

3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABAA receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity[1][2].

Invitro

The GAD activation is stereoselective for the R isomer of 3-methyl GABA relative to the corresponding S isomer[1].

Name

3-Methyl-GABA

CAS

1216629-00-3

Formula

C20H30N2O10S2

Molar Mass

522.59

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. R B Silverman, et al. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. J Med Chem. 1991 Jul;34(7):2295-8. [2]. Z. YANG, et al. MOLECULAR INTERACTIONS OF GABA ANALOGUES AGAINST THE α+β-INTERFACE OF GABAARECEPTOR: DOCKING AND MOLECULAR DYNAMICS STUDIES. Digest Journal of Nanomaterials and Biostructures, Vol. 10, No. 3, July -September 2015.

PeptideDB

3-Methyl-GABA

CAS: 1216629-00-3 F: C20H30N2O10S2 W: 522.59