| Bioactivity | 3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist[1]. |
| Target | GABAB |
| Invitro | 3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84-0.23 μM)[2]3-Aminopropylphosphinic acid acts as an anti-aging substance for skin[4]. |
| In Vivo | 3-Aminopropylphosphinic acid (5 mg/kg; i.v.) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. Animal Model: |
| Name | 3-Aminopropylphosphinic acid |
| CAS | 103680-47-3 |
| Formula | C3H10NO2P |
| Molar Mass | 123.09 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9. [2]. Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6. [3]. Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24. [4]. Cho Youn-Ki, et al. 3-Aminopropyl dihydrogen phosphate (3-APPA; 3-aminopropane phosphoric acid); a novel anti-aging substance. Journal of Investigative Dermatology, vol. 4, no. 106, 2015, p. 895. |
3-Aminopropylphosphinic acid
CAS: 103680-47-3 F: C3H10NO2P W: 123.09
3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selectiv
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.