3,4-Dimethoxychalcone_product_DataBase

Bioactivity	3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1].
Invitro	3,4-Dimethoxychalcone (30 μM, 8 小时) 增加 HepG2 和 U2OS 细胞中的自噬通量[1]。3,4-Dimethoxychalcone (30 μM, 6 小时) 刺激 U2OS 细胞中的 TFEB 和 TFE3 转位到细胞核中[1]。 0 --> 3,4-Dimethoxychalcone 相关抗体:
In Vivo	3,4-Dimethoxychalcone (230 mg/kg for intraperitoneal injection) 诱导雌性 C57/BL6 小鼠肝脏和心脏组织 TFEB 和 TFE 3 的核易位[1]。
Name	3,4-Dimethoxychalcone
CAS	5416-71-7
Formula	C17H16O3
Molar Mass	268.31
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11(1):21781. [2]. Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11(11):e10469.

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