2-Chloro-N-cyclopentyl-2′-C-methyladenosine_product_DataBase

Bioactivity

2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs)[1][2].

In Vivo

2’-MeCCPA (1 nM-1 M) at reperfusion significantly reduces infarct size to risk ratio in male Sprague-Dawley rats[1].

Name

2-Chloro-N-cyclopentyl-2′-C-methyladenosine

CAS

205171-12-6

Formula

C16H22ClN5O4

Molar Mass

383.83

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. J Bhandal, et al. Adenosine a1 receptor activation can protect the myocardium from ischaemia reperfusion injury post reperfusion. BMJ Journals. Volume 104, Issue Suppl 3. [2]. Muntean BS, et al. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268.

PeptideDB

2-Chloro-N-cyclopentyl-2′-C-methyladenosine

CAS: 205171-12-6 F: C16H22ClN5O4 W: 383.83