| Bioactivity | 2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1]. | ||||||||||||
| Invitro | 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1]. | ||||||||||||
| Name | 2,5-Dihydroxyacetophenone | ||||||||||||
| CAS | 490-78-8 | ||||||||||||
| Formula | C8H8O3 | ||||||||||||
| Molar Mass | 152.15 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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2,5-Dihydroxyacetophenone
CAS: 490-78-8 F: C8H8O3 W: 152.15
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activ
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