2,4′-Dihydroxybenzophenone_product_DataBase

Bioactivity

2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].

In Vivo

2,4′-Dihydroxybenzophenone (6.25-25 μM) 可降低 LPS 显微注射的斑马鱼幼虫的死亡率和形态异常、恢复心率，并减轻巨噬细胞和中性粒细胞向炎症部位的募集[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS

131-56-6

Formula

C13H10O3

Molar Mass

214.22

Appearance

固体

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7(5):1320-1334. [2]. Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28(13):5017.

PeptideDB

2,4′-Dihydroxybenzophenone

CAS: 131-56-6 F: C13H10O3 W: 214.22