2,2′-Dihydroxychalcone_product_DataBase

Bioactivity	2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties[1][2].
Invitro	2,2′-Dihydroxychalcone （1-50 μM；72 小时）会导致存活率呈剂量依赖性降低，72 小时时 PC3 细胞凋亡随之增加，24 小时治疗时克隆形成存活率降低[ 1]。2,2′-Dihydroxychalcone （15 μM；6-48 小时）显着降低 Cyclin A 和 Cyclin B1、cdc2 和 PIK1 的蛋白水平[1]。PC3 cells1 μM, 5 μM, 15 μM, 25 μM, 50 μM72 hPC3 cells15 μM6 h, 12 h, 24 h, 48 hInduced cell cycle arrest in PC3 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 2,2′-Dihydroxychalcone 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	15131-80-3
Formula	C15H12O3
Molar Mass	240.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ahmed Q Haddad, et al. Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr Cancer. 2010;62(5):668-81. [2]. Kenneth Goh, et al. 2,2'-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D. Mol Med Rep. 2008 Jul-Aug;1(4):575-9.

PeptideDB

2,2′-Dihydroxychalcone

CAS: 15131-80-3 F: C15H12O3 W: 240.25