| Bioactivity | 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity[1][2]. | ||||||||||||
| In Vivo | 2,2'-Bipyridine (40 mg/kg; s.c.; once) produces an initial hyperglycemia (an increase of 53.8 mg/100 mL at 2 hours) followed by a transient hypoglycemicphase at 24 hours and does not produce permanent diabetes[2]. Animal Model: | ||||||||||||
| Name | 2,2'-Bipyridine | ||||||||||||
| CAS | 366-18-7 | ||||||||||||
| Formula | C10H8N2 | ||||||||||||
| Molar Mass | 156.18 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468. [2]. Kenny A D, et al. The hyperglycemic activity of 2, 2'-bipyridine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 135(3): 317-322. |