1-(1-Naphthyl)piperazine hydrochloride_product_DataBase

Bioactivity	1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].
Invitro	1-1-Naphthylpiperazine hydrochloride (50-300 μM) 通过在 S 期阻滞细胞周期，诱导细胞凋亡以及 ROS 生产的方式，抑制黑色素瘤细胞 MNT-1，IC50 为 163.6 μM[1]。1-1-Naphthylpiperazine hydrochloride (0-200 μM) 可以调节与紫外线诱导的免疫抑制有关的基因表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 1-(1-Naphthyl)piperazine hydrochloride 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	1-1-Naphthylpiperazine hydrochloride (1 μM，腹腔注射，单剂量) 通过核苷酸切除修复 (NER) 机制促进紫外线辐射诱导的 DNA 修复，从而预防 UVB 暴露的 C57BL/6 小鼠的免疫抑制并干扰光致癌作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	104113-71-5
Formula	C14H17ClN2
Molar Mass	248.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Menezes AC, et al., Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78. [2]. Sreevidya CS, et al., Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May;130(5):1428-37.

PeptideDB

1-(1-Naphthyl)piperazine hydrochloride

CAS: 104113-71-5 F: C14H17ClN2 W: 248.75