1,6,7-Trihydroxyxanthone_product_DataBase

Bioactivity	1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].
Invitro	1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) 抑制 HepG2、Bel7404 细胞的细胞增殖[1]。1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) 诱导 HepG2 细胞凋亡[1].1,6,7-Trihydroxyxanthone 降低 Bmi-1 表达并增加 P14、P16 的蛋白表达水平[1]。1,6,7-Trihydroxyxanthone 在 HepG2、Bel7404 细胞中诱导 MiR-218 上调[1]。 Cell Proliferation Assay[1] Cell Line:
Name	1,6,7-Trihydroxyxanthone
CAS	25577-04-2
Formula	C13H8O5
Molar Mass	244.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fu WM, et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 2015 Jan;20(1):75-82.

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