1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin_product_DataBase

Bioactivity	1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (1,2,3,6,7,8-HxCDD) is an AHR agonist, with reported gene assay EC50 values of 5.4 nM at 4 hours and 9.3 nM at 8 hours. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (at doses of 0.5 and 2 µg/kg) has been shown to reduce the production of antibodies against sheep red blood cells in mice. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin is an environmental pollutant, found in animal feed and detected in the air near municipal waste incinerators[1].
CAS	57653-85-7
Formula	C12H2Cl6O2
Molar Mass	390.86
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hu SW, et al. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere. 2004 Apr;55(4):611-20. [2]. Pajurek M, et al. Feed as a source of dioxins and PCBs. Chemosphere. 2022 Dec;308(Pt 1):136243. [3]. Xu T, et al. A rapid and reagent-free bioassay for the detection of dioxin-like compounds and other aryl hydrocarbon receptor (AhR) agonists using autobioluminescent yeast. Anal Bioanal Chem. 2018 Feb;410(4):1247-1256. [4]. Holsapple MP, et al. Suppression of humoral antibody production by exposure to 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin. J Pharmacol Exp Ther. 1984 Dec;231(3):518-26.

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