| Bioactivity | (Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1]. | ||||||||||||
| Invitro | (Rac)-Tavapadon ((Rac)-PF-06649751; compound 32) has EMAXs of 118% and 30% in the GS activation assay and the β-arrestin2 recruitment assay[1]. | ||||||||||||
| Name | (Rac)-Tavapadon | ||||||||||||
| CAS | 1643462-64-9 | ||||||||||||
| Formula | C19H16F3N3O3 | ||||||||||||
| Molar Mass | 391.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182. |
(Rac)-Tavapadon
CAS: 1643462-64-9 F: C19H16F3N3O3 W: 391.34
(Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.