| Bioactivity | (R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent[1][2]. | |||||||||
| Invitro | (R)-Mephenytoin can be N-demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the metabolite 5-phenyl-5-ethylhydantoin (nirvanol)[1]. | |||||||||
| Name | (R)-Mephenytoin | |||||||||
| CAS | 71140-51-7 | |||||||||
| Formula | C12H14N2O2 | |||||||||
| Molar Mass | 218.25 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Meier UT, et, al. Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. Anal Biochem. 1985 Dec;151(2):286-91. [2]. Relling MV, et, al. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther. 1990 Jan;252(1):442-7. |