| Bioactivity | (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2]. | ||||||||||||
| Name | (E)-AG 556 | ||||||||||||
| CAS | 133550-41-1 | ||||||||||||
| Formula | C20H20N2O3 | ||||||||||||
| Molar Mass | 336.38 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34(6):1896-907. [2]. George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74(3):314-8. |