| Bioactivity | (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. | ||||||||||||
| Invitro | (-)-Huperzine A (1 µM; 2 hours) attenuates Aβ23-35 (20 µM)-induced neuronal injury[2].(-)-Huperzine A (100 μM) reversibly inhibits the NMDA-induced current (IC50=126 μM) in whole-cell voltage-clamp recording in CA1 pyramidal neurons acutely dissociated from rat hippocampus[3]. | ||||||||||||
| Name | (-)-Huperzine A | ||||||||||||
| CAS | 102518-79-6 | ||||||||||||
| Formula | C15H18N2O | ||||||||||||
| Molar Mass | 242.32 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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(-)-Huperzine A
CAS: 102518-79-6 F: C15H18N2O W: 242.32
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzin
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