| Bioactivity | (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs)[1]. | |||||||||
| Invitro | (+)-Intermedine (1.1-30 μM; 24 hours) exhibits significant cytotoxicity at 30 μM and reduces cell viability in a concentration dependent manner in neural progenitor cells (NPCs)[1]. (+)-Intermedine showsno differentiation impairment[1]. Cell Cytotoxicity Assay[1] Cell Line: | |||||||||
| Name | (+)-Intermedine | |||||||||
| CAS | 10285-06-0 | |||||||||
| Formula | C15H25NO5 | |||||||||
| Molar Mass | 299.36 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Yan Zhang, et al. Analysis of pyrrolizidine alkaloids in Eupatorium fortunei Turcz. and their in vitro neurotoxicity. Food Chem Toxicol. 2021 May;151:112151. |