Title: Valnoctamide

CAS Registry Number: 4171-13-5

CAS Name: 2-Ethyl-3-methylpentanamide

Additional Names: 2-ethyl-3-methylvaleramide; a-ethyl-b-methylvaleramide; valmethamide

Manufacturers' Codes: McN-X-181

Trademarks: Axiquel (McNeil); Nirvanil (SKB)

Molecular Formula: C8H17NO

Molecular Weight: 143.23

Percent Composition: C 67.08%, H 11.96%, N 9.78%, O 11.17%

Literature References: Isomer of valpromide, q.v. Prepn: Freifelder et al., J. Org. Chem. 26, 203 (1961). GLC determn in plasma: M. Bialer, B. Hoch, J. Chromatogr. 337, 408 (1985). Clinical pharmacokinetics: M. Bialer et al., Eur. J. Clin. Pharmacol. 38, 289 (1990).

Properties: Crystals, mp 113.5-114°. Sol in water.

Melting point: mp 113.5-114°

Therap-Cat: Anxiolytic.

Keywords: Anxiolytic.