Title: Triamterene

CAS Registry Number: 396-01-0

CAS Name: 6-Phenyl-2,4,7-pteridinetriamine

Additional Names: 2,4,7-triamino-6-phenylpteridine; 6-phenyl-2,4,7-triaminopteridine; ademin(e); pterofen; pterophene

Manufacturers' Codes: NSC-77625; SKF-8542

Trademarks: Dyren (Sejin); Dyrenium (SKB); Dytac (Bridge); Jatropur (Procter & Gamble); Teriam (Roussel Diamant); Triteren (Sumitomo); Urocaudal (Jorba)

Molecular Formula: C12H11N7

Molecular Weight: 253.26

Percent Composition: C 56.91%, H 4.38%, N 38.71%

Literature References: Prepn: Spickett, Timmis, J. Chem. Soc. 1954, 2887; Pachter, J. Org. Chem. 28, 1191 (1963); Weinstock, Wiebelhaus, US 3081230 (1963 to SK & F); Osdene et al., J. Med. Chem. 10, 431 (1967). Review: Ther. Triamteren Wien. Symp. 1966, K. Fellinger, Ed. (Georg Thieme, Vienna, 1967). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. Excip. 23, 571-605 (1994).

Properties: Yellow plates from butanol, mp 316° (Spickett, Timmis); also reported as crystals from DMF, mp 327° (Osdene et al.). pKa 6.2. Practically insol in ether. Sol in formic acid. Slight sol in water (1 in 1000), ethanol (1 in 3000), chloroform (1 in 4000). uv max (4.5% formic acid): 356 nm (e 21000).

Melting point: mp 316° (Spickett, Timmis); mp 327° (Osdene et al.)

pKa: pKa 6.2

Absorption maximum: uv max (4.5% formic acid): 356 nm (e 21000)

Therap-Cat: Diuretic.

Keywords: Diuretic.