Title: Povidone-Iodine

CAS Registry Number: 25655-41-8

CAS Name: 1-Ethenyl-2-pyrrolidinone homopolymer compd with iodine

Additional Names: 1-vinyl-2-pyrrolidinone polymers, iodine complex; iodine-polyvinylpyrrolidone complex; polyvinylpyrrolidone-iodine complex; PVP-I

Trademarks: Betadine (Purdue Frederick); Betaisodona (Mundipharma); Braunol (Braun Melsungen); Braunosan H (Braun Melsungen); Disadine D.P. (Stuart); Efodine (Fougera); Inadine (J & J); Isodine (Blair); Proviodine (Rougier); Traumasept (Wolff)

Literature References: An iodophor, q.v., prepd by Beller, Hosmer, US 2706701; Hosmer, US 2826532; Siggia, US 2900305 (1955, 1958, and 1959, all to GAF). Prepn, history and use: Shelanski, Shelanski, J. Int. Coll. Surg. 25, 727 (1956).

Properties: Yellowish-brown, amorphous powder with slight characteristic odor. Aq solns have a pH near 2 and may be made more neutral (but less stable) by the addition of sodium bicarbonate. Sol in alc, water. Practically insol in chloroform, carbon tetrachloride, ether, solvent hexane, acetone. Solns do not give the familiar starch test when freshly prepared.

Therap-Cat: Anti-infective (topical).

Therap-Cat-Vet: Anti-infective (topical).

Keywords: Antiseptic/Disinfectant; Halogens/Halogen Containing Compounds.