Title: Margatoxin

CAS Registry Number: 145808-47-5

Additional Names: MgTX

Molecular Formula: C178H286N52O50S7

Molecular Weight: 4178.95

Percent Composition: C 51.16%, H 6.90%, N 17.43%, O 19.14%, S 5.37%

Literature References: Peptide toxin isolated from the new world scorpion, Centruroides margaritatus, consists of 39 amino acids with 3 disulfide bridges. Selectively inhibits voltage-gated potassium channels. Isoln and characterization: M. Garcia-Calvo et al., J. Biol. Chem. 268, 18866 (1993). Synthesis: M. A. Bednarek et al., Biochem. Biophys. Res. Commun. 198, 619 (1994). NMR determn of three dimensional structure: B. A. Johnson et al., Biochemistry 33, 15061 (1994). Use as an affinity label for potassium channels: H.-G. Knaus et al., ibid. 34, 13627 (1995); H. S. Fischer, A. Saria, Neurosci. Lett. 263, 208 (1999).

Use: Biochemical probe.