Title: Levocabastine

CAS Registry Number: 79516-68-0

CAS Name: [3S-[1(cis),3a,4b]]-1-[4-Cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid

Additional Names: (-)-trans-1-[cis-4-cyano-4-(p-fluorophenyl)cyclohexyl]-3-methyl-4-phenylisonipecotic acid; (-)-cabastine

Molecular Formula: C26H29FN2O2

Molecular Weight: 420.52

Percent Composition: C 74.26%, H 6.95%, F 4.52%, N 6.66%, O 7.61%

Literature References: Histamine H1-receptor antagonist. Prepn: R. Stokbroekx et al., EP 34415; eidem, US 4369184 (1981, 1983 both to Janssen); and pharmacology: R. A. Stokbroekx et al., Drug Dev. Res. 8, 87 (1986). Pharmacology: K. Tasaka et al., Arzneim.-Forsch. 40, 1295 (1990). Clinical pharmacology: N. Rombaut et al., Ann. Allergy 67, 75 (1991). Clinical trial in children with allergic conjunctivitis: M. Rimas et al., Allergy 45, 18 (1990); in allergic rhinitis: M. Schata et al., J. Allergy Clin. Immunol. 87, 873 (1991). Review of pharmacology and therapeutic use: K. L. Dechant, K. L. Goa, Drugs 41, 202-224 (1991).

 

Derivative Type: Hydrochloride

CAS Registry Number: 79547-78-7

Manufacturers' Codes: R-50547

Trademarks: Levophta (Chauvin); Livostin (Novartis)

Molecular Formula: C26H29FN2O2.HCl

Molecular Weight: 456.98

Percent Composition: C 68.34%, H 6.62%, F 4.16%, N 6.13%, O 7.00%, Cl 7.76%

 

Therap-Cat: Antihistaminic.

Keywords: Antihistaminic.