Title: Danaparoid

Additional Names: Mucoglucoronan

Literature References: Low molecular weight heparinoid derived from hog intestinal mucosa. Mixture of glycosaminoglycans with a mean mol wt of 6000 Da (range 4000-10000 Da). Consists of heparan sulfate (~83%), dermatan sulfate (~12%) and chondroitin sulfate (~5%). Prepn: A. L. M. Saunders et al., EP 66908; eidem, US 4438108 (1982, 1984 both to Akzo). Pharmacology: D. G. Meuleman et al., Thromb. Res. 27, 353 (1982). Determn in plasma: H. ten Cate et al., Clin. Chem. 30, 860 (1984). Series of articles on pharmacology and clinical efficacy: Haemostasis 22, 55-112 (1992). Clinical trial in deep venous thromboembolism: H. W. de Valk et al., Ann. Intern. Med. 123, 1 (1995).

 

Derivative Type: Sodium salt

Manufacturers' Codes: Org-10172

Trademarks: Orgaran (Organon)

 

Therap-Cat: Antithrombotic.

Keywords: Antithrombotic.