Title: Benztropine Mesylate

CAS Registry Number: 132-17-2

CAS Name: 3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate

Additional Names: 3a-(diphenylmethoxy)-1aH,5aH-tropane methanesulfonate; benztropine methanesulfonate; tropine benzohydryl ether methanesulfonate

Trademarks: Cogentin (Merck & Co.); Cogentinol (Astra)

Molecular Formula: C22H29NO4S

Molecular Weight: 403.53

Percent Composition: C 65.48%, H 7.24%, N 3.47%, O 15.86%, S 7.95%

Literature References: Anticholinergic. Prepd by the action of diphenyldiazomethane on tropine: Phillips, US 2595405 (1952 to Merck & Co.). Crystal structure: P. G. Jones et al., Acta Crystallogr. B34, 3125 (1978).

Properties: Crystals from acetone + ether, mp 143°. uv max: 259 nm (EM = 437). Soluble in water. pH about 6.

Melting point: mp 143°

Absorption maximum: uv max: 259 nm (EM = 437)

Therap-Cat: Antiparkinsonian.

Keywords: Antiparkinsonian; Antimuscarinic.