| CAS | 63958-90-7 |
| Sequence | Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH |
| Sequence Single | pEAKSQGGSN |
| Molecular Formula | C33H54N12O15 |
| Molecular Weight | 858.86 |
| Synonyms | Serum Thymic Factor, STF, Thymulin |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Immunomodulating Agents|Inflammation Research |
| Description | Thymic Factor also called Serum Thymic Factor, STF, Thymulin, is a peptide hormone, it has anti-inflammatory and immunomodulatory activity, at the presence of Zn(II). Thymulin showed promising results in experimental models of lung diseases as well as potential as an analgesic peptide. |
| References | 1. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. T.L.Davis et al., PLoS Biology, 8, e1000439 (2010) 2. Immunomodulatory role of thymulin in lung diseases. M.Santos et al., Expert Opin. Ther. Targets, 14, 131 (2010) 3. The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin. P.C.Reggiani et al., Ann. N. Y. Acad. Sci., 1153, 98 (2009) 4. Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants. J.F.Bach et al., Bull. Inst. Pasteur, 325 (1978) 5. Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway. S.C.Land and F.Darakshan, Am. J. Physiol. Lung Cell. Mol. Physiol., 286, L473 (2004) 6. Immunomodulatory potential of thymulin-Zn(2+) in the alveolar epithelium: amelioration of endotoxin-induced cytokine release and partial amplification of a cytoprotective IL-10-sensitive pathway. T.L.K.Low and A.L.Goldstein, Springer Semin. Immunopathol., 2, 169 (1979) 7. Immunohistochemical evidences showing the presence of thymulin containing cells located in involuted thymus and in peripheral lymphoid organs. T.Henriques-Coelho et al., Endocrinology, 149, 4367 (2008) |