| CAS | 60786-59-6 |
| Sequence | H-Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bond) |
| Sequence Single | CYITNCGLG-NH2 |
| Molecular Formula | C39H61N11O12S2 |
| Molecular Weight | 940.11 |
| Synonyms | TGOT |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | (Thr4,Gly7)-Oxytocin also called TGOT, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. (Thr4,Gly7)-Oxytocin exhibits a 640-fold increase in oxytocic/ antidiuretic selectivity relative to oxytocin. |
| References | 1. Structure-activity relationships of mammalian, chicken, and salmon gonadotropin releasing hormones in vivo in goldfish. R.E.Peter et al., Gen. Comp. Endocrinol., 58, 231 (1985) 2. Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. M.Zaninetti and M.Raggenbass, Eur. J. Neurosci., 12, 3975 (2000) 3. Synthesis and some pharmacological properties of oxytocin and vasopressin analogues with sarcosine or N-methyl-L-alanine in position 7. J.Lowbridge et al., J. Med. Chem., 20, 120 (1977) 4. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Lily R Barrett, et al. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. 5. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Binqi Hu, et al. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. 6. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. M R Melis, et al. Regul Pept. 1997 Mar 26;69(2):105-11. |