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Tau Peptide (294-305) (human)

CAS No.: 1428135-29-8

Tau Peptide (294-305) (human), conjugated to KLH via an N-terminal cysteine was tested as anti-tau vaccine. Tau Peptide
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CAS 1428135-29-8
Sequence H-Lys-Asp-Asn-Ile-Lys-His-Val-Pro-Gly-Gly-Gly-Ser-OH
Sequence Single KDNIKHVPGGGS
Molecular Formula C51H85N17O17
Molecular Weight 1208.32
Synonyms Microtubule-Associated Protein Tau (610-621) (human)
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Alzheimer’s Disease|Tau Peptides
Description Tau Peptide (294-305) (human), conjugated to KLH via an N-terminal cysteine was tested as anti-tau vaccine. Tau Peptide (294-305) (human) might prevent formation of the beta/beta-helix structure of protofilaments involving residues 306-378.
References 1.  HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition. B.Riteau et al., Int. Immunol., 13, 193 (2001) 2.  First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model. E. Kontsekova et al., Alzheimers Res. Ther., 6, 44 (2014)