| CAS | 68060-49-1 |
| Sequence | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH |
| Sequence Single | RPKPQQF |
| Molecular Formula | C41H65N13O10 |
| Molecular Weight | 900.05 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Substance P (1-7) is an amino-terminal fragment of substance P, it exerts depressor and bradycardic effects when applied to the nucleus tractus solitarius. It was also shown that this fragment, contrary to substance P, may reduce signs of opioid withdrawal in mice. |
| References | 1. Substance P(1-7) affects the expression of dopamine D2 receptor mRNA in male rat brain during morphine withdrawal. N.Fukuchi et al., J. Chem. Soc., Perkin Trans. I, 11149 (1992) 2. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Herrera-Marschitz M, et al. Brain Res. 1990 Jun 25;521(1-2):316-20. 3. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Sakurada T, et al. Neurosci Lett. 1988 Dec 19;95(1-3):281-5. |