| CAS | 120298-73-9 |
| Sequence | H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser-OH |
| Sequence Single | AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATS |
| Molecular Formula | C207H334N66O58 |
| Molecular Weight | 4675.34 |
| Synonyms | Hypercalcemia of Malignancy Factor (1-40) (human, mouse, rat), pTHrP (1-40) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Osteoporosis Research |
| Description | pTH-Related Protein (1-40) (human, mouse, rat) also called Hypercalcemia of Malignancy Factor (1-40) (human, mouse, rat), pTHrP (1-40), enhanced significantly, in a dose-related manner, the low Ca2+-stimulated pTH secretion in normal rats. Whitfield et al. observed that pTH-Related Protein (1-40) stimulates membrane-associated protein kinase C activity in rat spleen lymphocytes. |
| References | 1. PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid glands. E.Lewin et al., Kidney Int., 58, 71 (2000) 2. Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats. E.Lewin et al., Kidney Int., 64, 63 (2003) 3. C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), and the N-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase C activity in rat spleen lymphocytes. J.F.Whitfield et al., J. Cell. Physiol., 158, 518 (1994) 4. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. L.J.Suva et al., Science, 237, 893 (1987) |
pTH-Related Protein (1-40) (human, mouse, rat)
CAS No.: 120298-73-9
pTH-Related Protein (1-40) (human, mouse, rat) also called Hypercalcemia of Malignancy Factor (1-40) (human, mouse, rat)
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