| CAS | 121932-06-7 |
| Sequence | H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 |
| Sequence Single | TYADFIASGRTGRRNAI-NH2 |
| Molecular Formula | C80H130N28O24 |
| Molecular Weight | 1868.06 |
| Synonyms | Protein Kinase A Inhibitor (6-22), amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | PKA Inhibitor (6-22) amide also called Protein Kinase A Inhibitor (6-22), amide, is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice. |
| References | 1. Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. L.G.Iben et al., J. Biol. Chem., 282, 36829 (2007) 2. Structural basis for the low affinities of yeast cAMP-dependent and mammalian cGMP-dependent protein kinases for protein kinase inhibitor peptides. D.B.Glass et al., Biochemistry, 31, 1728 (1992) 3. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). G.D.Dalton et al., Neuropharmacology, 48, 648 (2005) 4. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Katz BM, et, al. Int J Pept Protein Res. 1989 Jun;33. |