| CAS | 1315378-69-8 |
| Sequence | H-Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ala-Val-Lys-Ile-OH |
| Sequence Single | YNVYGIEAVKI |
| Molecular Formula | C60H93N13O17 |
| Molecular Weight | 1268.47 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). pep2-AVKI does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD). |
| References | 1. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Daw et al (2000). Neuron 28 873 PMID: 11163273 2. NSF ATPase and α-/β-SNAPs disassemble the AMPA receptor-PICK1 complex. Hanley et al (2002). Neuron 34 53 PMID: 11931741 3. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Kim et al (2001). Proc.Natl.Acad.Sci.U.S.A. 98 11725 PMID: 11573007 4. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Li et al (1999). Nat.Neurosci. 2 972 PMID: 10526335 |