| CAS | 249537-73-3 |
| Sequence | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH |
| Sequence Single | MAGPHPVIVITGPHEE |
| Molecular Formula | C75H118N20O22S |
| Molecular Weight | 1683.95 |
| Synonyms | VIVIT peptide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | NFAT Inhibitor also called VIVIT peptide, is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. |
| References | 1. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. K.Tatemoto et al., Biochem. Biophys. Res. Commun., 251, 471 (1998) 2. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Aramburu J, et al. Science. 1999 Sep 24;285(5436):2129-33. 3. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Ma JD, et al. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264. |