| CAS | 99566-27-5 |
| Sequence | H-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 |
| Sequence Single | FLFQPQRF-NH2 |
| Molecular Formula | C54H76N14O10 |
| Molecular Weight | 1081.29 |
| Synonyms | NPFF, F-8-F-amide, Neuropeptide FF Morphine Modulating Neuropeptide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Neuropeptide FF also called NPFF, F-8-F-amide, Neuropeptide FF Morphine Modulating Neuropeptide, an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation. |
| References | 1. A Facile Method for the Transformation of N-(tert-Butoxycarbonyl) α-Amino Acids to N-Unprotected α-Amino Methyl Esters. B.C.Chen et al., J. Org. Chem., 64, 9294 (1999) 2. Role of the delta-opioid receptor in (1DMe)NPYF mediated antinociception. M.Xu et al., Peptides, 22, 33 (2001) 3. Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Cline et al (2007). Neuropeptides 41 433 PMID: 17936900 4. Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[35S]GTPγS binding. Gouarderes et al (2007). Neuropharmacology 52 376 PMID: 17011599 5. Pharmacology and signaling of MAS-related G protein-coupled receptors. Solinski et al (2014). Pharmacol.Rev. 66 570 PMID: 24867890 6. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Mankus JV, et al. Future Med Chem. 2012 Jun;4(9):1085-92. 7. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Jhamandas JH, et al. Front Endocrinol (Lausanne). 2013 Feb 7;4:8. |