| CAS | 87096-84-2 |
| Sequence | H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2 |
| Sequence Single | GNLWATGHFM-NH2 |
| Molecular Formula | C52H73N15O12S |
| Molecular Weight | 1132.31 |
| Synonyms | NMB |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | Neuromedin B also called NMB, a bombesin-linke peptide, binds to the bombesin receptors BRS1-4. Neuromedin B is expressed in the pituitary, brain, pancreas, adrenal and gastrointestinal tract. Its expression in adipose tissue appears to be regulated by changes in energy balance. Neuromedin B could inhibit food intake and modulates stress-related behavior. |
| References | 1. Galanin and galanin antagonists: molecular and biochemical perspectives. T.Bartfai et al., Trends Pharmacol. Sci., 13, 312 (1992) 2. Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. M.Pigeyre et al., Int. J. Obes., 34, 478 (2010) 3. Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid hormones and neuromedin B on thyrotropin secretion. T.M.Ortiga-Carvalho et al., Regul. Pept., 67, 47 (1996) 4. Stress and eating: a dual role for bombesin-like peptides. Z.Merali et al., Front. Neurosci., 7, 193 (2013) 5. Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. N.Minamino et al., Biochem. Biophys. Res. Commun., 114, 541 (1983) 6. Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance. N.Hoggard et al., J. Mol. Endocrinol., 39, 199 (2007) |