| CAS | 126768-94-3 |
| Sequence | H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH |
| Sequence Single | QKRPSQRSKYL |
| Molecular Formula | C60H103N21O17 |
| Molecular Weight | 1390.61 |
| Synonyms | MBP (4-14) (bovine), QKRPSQRSKYL |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Multiple Sclerosis |
| Description | Myelin Basic Protein (4-14) also called MBP (4-14) (bovine), QKRPSQRSKYL, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective protein kinase C (PKC) substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts. |
| References | 1. A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. Farrar YJ, et al. Biochem Biophys Res Commun. 1991;180(2):694-701. 2. A synthetic peptide substrate for selective assay of protein kinase C. Yasuda I, et al. Biochem Biophys Res Commun. 1990;166(3):1220-1227. |