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Mating Factor α

CAS No.: 59401-28-4

Mating Factor α also called alpha-Factor, α-Factor, Pheromone α-Factor, a-Mating Factor, yeast, a 13-amino acid phero
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CAS 59401-28-4
Sequence H-Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr-OH
Sequence Single WHWLQLKPGQPMY
Molecular Formula C82H114N20O17S
Molecular Weight 1684.01
Synonyms alpha-Factor, α-Factor, Pheromone α-Factor, a-Mating Factor, yeast
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Description Mating Factor α also called alpha-Factor, α-Factor, Pheromone α-Factor, a-Mating Factor, yeast, a 13-amino acid pheromone secreted by haploid α-cells of Saccharomyces cerevisiae, binds to Ste2p, a transmembrane G-protein-coupled receptor present on haploid α-cells, and activates a signal transduction pathway required for conjugation and mating.
References 1.  A series of kokumi peptides impart the long-lasting mouthfulness of matured Gouda cheese. S.Toelstede et al., J. Agric. Food Chem., 57, 1440 (2009) 2.  Purification and amino acid sequence of mating factor from Saccharomyces cerevisiae. T.Tanaka et al., J. Biochem., 82, 1681 (1977) 3.  Site of action of mating factor in a-mating type cell of Saccharomyces cerevisiae. T.Tanaka and H.Kita, Biochem. Biophys. Res. Commun., 83, 1319 (1978) 4.  The effect of alpha-factor on the rate of cell-cycle initiation in Saccharomyces cerevisiae: alpha-factor modulates transition probability in yeast. G.P.Samokhin et al., Exp. Cell Res., 131, 267 (1981) 5.  Structure-activity relationships of the yeast alpha-factor. D.Stötzler et al., Eur. J. Biochem., 69, 397 (1976) 6.  Amino acid substitution of mating factor of Saccharomyces cerevisiae structure-activity relationship. F.Naider and J.M.Becker, CRC Crit. Rev. Biochem., 21, 225 (1986) 7.  Synthesis of the mating factor of Saccharomyces cerevisiae and its truncated peptides : the structure-activity relationship. Y.Masui et al., Biochem. Biophys. Res. Commun., 86, 982 (1979) 8.  Yeast mating pheromone alpha factor inhibits adenylate cyclase. Y.Masui et al., Biochem. Biophys. Res. Commun., 78, 534 (1977) 9.  alpha-Factor-mediatd modification of a 32P-labeled protein by MATa cells of Saccharomyces cerevisiae. H.H.Liao and J.Thorner, Proc. Natl. Acad. Sci. USA, 77, 1898 (1980) 10.  Yeast pheromone alpha-factor is synthesized as a high molecular weight precursor. D.B.Finkelstein and L.McAlister, J. Biol. Chem., 256, 2561 (1981)